Chapel Hill · North Carolina

39 Chapel Hill startups

39 startups headquartered in Chapel Hill are tracked in the Triangle Startups directory, with the largest clusters in SaaS, Biotech, and MedTech. Chapel Hill is home to the University of North Carolina at Chapel Hill. Every company here is sourced by hand from primary records, then linked to its full profile.

SaaS9Biotech7MedTech6Healthtech5

Directory snapshot

What the Chapel Hill startup directory shows

SaaS is the largest recorded cluster, with 9 startups. Of 20 startups with a recorded funding stage, 17 are at grant, pre-seed, or seed. Reviewed jobs records currently show 12 open roles across 3 companies.

tracked startups: 39
in SaaS: 9
grant through seed: 17

By stagePre Seed7Seed6Grant4Series A2Series B1

Hiring in Chapel Hill

12 reviewed open roles

See the jobs board

Well7 rolesHealthtech · Series BAI-powered health engagement platform

CData Software4 rolesSaaSData-connectivity and integration software: standards-based drivers and a platform that gives applications, analytics tools, and AI agents real-time SQL access to more than 350 enterprise data sources. Launched Connect AI, a managed Model Context Protocol platform, in 2025.

SiteBridge Research1 roleHealthtechCommunity clinical-trials organization connecting physicians and patients to research opportunities.

Local startup infrastructure

Where Chapel Hill startups build

Accelerators, venture studios, and other local programs that work directly with founders in Chapel Hill.

Venture StudioEshelman InnovationUNC Eshelman School of Pharmacy's healthcare innovation arm. Operates a Therapeutics Accelerator (oncology, neuroscience, infectious diseases) and a Venture Studio that incubates digital-health startups around opioid-use disorder, food insecurity, and clinical decision-making.AcceleratorLaunch Chapel HillDowntown Chapel Hill accelerator and coworking space, run as a partnership with UNC, the Town of Chapel Hill, and Orange County. Cohort-based accelerator program runs alongside member coworking.

Startups headquartered in Chapel Hill

Aquagenx

Other

ARGOS Biosystems

MedTech · Pre Seed

Bark Insights

Healthtech

Blue Sky Robotics

Other

Carolina Cloud

DeepTech · Seed

Carolina Instruments

MedTech · Pre Seed

CData Software

SaaS

ColoWrap

MedTech

DelAQUA Pharmaceuticals

Biotech

Ensembled

Consumer · Grant

Fizz Studio

SaaS

GameFlo

SaaS · Seed

GeneVentiv Therapeutics

Biotech · Pre Seed

InoKare Therapeutics

Biotech · Seed

iOrganBio

Biotech · Seed

Kingscrowd

Fintech

nOS

EdTech

Nuvio

Other

Parity

SaaS

Perotech

DeepTech

Persistence Therapeutics

Biotech · Seed

PlugVerse

Consumer · Pre Seed

Quinsite

Healthtech

RepVue

SaaS

RO-bot

SaaS · Grant

Safeli Shop

Consumer

Sensible

MedTech

SiteBridge Research

Healthtech

SonoVascular

MedTech · Series A

STEM PLUG

EdTech · Grant

Swarm

SaaS · Pre Seed

Swik AI

Fintech · Pre Seed

Thoracic Innovations

MedTech · Pre Seed

TransChromix LLC

Biotech · Grant

Triangle Biotechnology

Biotech

Truentity Health

Healthtech · Series A

Ultisim

SaaS

Virnika

SaaS · Seed

Well

Healthtech · Series B

Browsing is free. Opening a company shows the basics; founders, funding, and signals are in the full profile behind a free account. Open roles across Triangle companies are tracked on the jobs page. Numbers refresh from the database.