25 Morrisville startups

374Water

Climate

Cleantech and services company (NASDAQ: SCWO) commercializing AirSCWO, a supercritical water oxidation technology that destroys hazardous and non-hazardous organic contaminants, including PFAS "forever chemicals," in wastewater, sludges, and other waste streams, converting them into clean reusable water, inert minerals, and recoverable energy. The technology was invented at Duke University. Formed in 2018, the company went public through an April 2021 reverse merger with PowerVerde and uplisted to the Nasdaq Capital Market in June 2022. Headquartered in Morrisville, NC, it serves industrial, federal, and municipal customers.

Builds anti-jamming and signal-assurance systems for wireless communications and navigation in contested environments.

Clinical-stage drug developer with two candidates: forvisirvat (SP-624), a SIRT6 activator in Phase 2b/3 for major depressive disorder, and RABI-767 for predicted severe acute pancreatitis.

Develops small-molecule CB1 cannabinoid receptor antagonists for liver disease, Prader-Willi syndrome and cannabis use disorder.

Develops vaccine and immunology technologies, including a virus-like-particle platform.

Codetta Bio

Biotech · Seed

Advanced multi-omic biomarker measurement tools for personalized health

Morrisville e-commerce company selling cultures and supplies for making yogurt, kefir, sourdough and other fermented foods at home.

DG Matrix

DeepTech · Series A

Power-infrastructure company building solid-state transformers and the Interport software-driven power platform for AI data centers, grid, microgrid, and fleet-electrification use cases.

DMC Biotechnologies

Biotech

Morrisville precision-fermentation biomanufacturer producing bio-identical natural compounds at scale via the proprietary Dynamic Metabolic Control platform; lead product line is fermented KeyPura inositols.

Preclinical biotech developing a bispecific aptamer drug that blocks VEGF and IL-8, starting with retinal diseases such as wet AMD and diabetic macular edema.

Morrisville digital ticketing company for venues, festivals and attractions, led by Joe Kustelski and backed by Parthenon Capital.

Inceptor Bio

Biotech · Series A

Cell therapy company developing next-generation engineered cell therapies for solid tumors.

Develops inhaled muco-trapping monoclonal antibodies for acute respiratory infections.

JupiterOne

SaaS · Series C

Cybersecurity SaaS for cyber-asset attack-surface management: it aggregates asset and relationship data across an organization's cloud and security tools to map and secure the full attack surface.

K4Connect

Healthtech · Series B

Enterprise connected-life technology for senior-living communities: it integrates smart-home devices, resident engagement, and caregiver tools into one platform used across continuing-care, independent-living, and assisted-living communities.

Lindy Biosciences

Biotech · Series A

Drug formulation technology with microglassification delivery systems

Locus Biosciences

Biotech · Series B

Morrisville clinical-stage biotech engineering bacteriophage therapeutics with CRISPR-Cas3 payloads for antimicrobial-resistant bacterial infections and microbiome / inflammatory diseases.

Morrisville self-publishing and print-on-demand company founded by Red Hat co-founder Bob Young, a certified B Corporation since 2016.

NALA Membranes

Climate · Series A

Morrisville-based advanced-materials startup developing chlorine-tolerant membranes for seawater desalination; technology aims to triple operating life vs conventional membranes.

Morrisville digital-marketing platform for multi-location brands and franchises, founded by Brendan Morrissey.

Develops AAV gene therapies for mucopolysaccharidoses, including Hurler, Hunter and Sanfilippo syndromes, and other rare neurogenetic diseases.

Unique, maintenance free plants

Creates the world’s most advanced holders, stages, and specimen supports for electron microscopy

Susteon

Climate

Morrisville company developing and licensing materials and processes for carbon capture, hydrogen, and low-carbon fuels and chemicals.

Trio Labs

DeepTech · Growth

Additive manufacturing company whose RIPL process produces precision metal and ceramic parts at micron-scale resolution.