Investors

Healthcare VC with $900M+ under management across 7 funds.

410 MedicalTen63 TherapeuticsIMMvention TherapeutixAer TherapeuticsAltis BiosystemsAtsena Therapeutics

Durham pre-seed and seed fund for North Carolina software startups, founded in 2023 by Joe Colopy and Jenn Summe and part of Colopy Ventures alongside Jurassic Capital and GrepBeat. Structured as an AngelList rolling fund open to outside angels since December 2023. Targets companies with a product in market and paying customers, plans 50 to 60 investments over the life of the fund, and reserves about 70% of its capital for follow-ons in its top-quartile companies.

FirmProScale Social AIKeebler HealthOpineBristlesCivicReach

Venture arm of Duke University, investing in Duke-connected companies from offices in Durham. The portfolio spans consumer, enterprise, and life science nationally; Triangle holdings include Tune Therapeutics, restor3d, Pryon, Teamworks, and Vulcan Elements.

410 MedicalVulcan ElementsTen63 TherapeuticsExtellisHHowsoLevitate

Grant and investment vehicle for NC startups.

Scale Social AICarolina InstrumentsCivicReachEEnsembledLukera Energymindr

Seed stage B2B software in the Southeast. 43+ investments.

Truentity HealthCycle LabsElement451AdwerxMap My CustomersSift Media

Duke Innovation & Entrepreneurship program

Grid IntelligenceHelianJeaniServ TechnologiesToilemetryVoxIntel AI

B2B software VC. 39 portfolio companies.

CloneableLevitateServiceTradeSpiffy

Angel network connecting NC State alumni investors with NC State-affiliated startups, run out of the university's Office of Research and Innovation. Members have invested more than $20M since the network's 2016 founding.

SonoVascularHHowsoReveal MobileSimpliworks

Angel network for the UNC-Chapel Hill community, pairing alumni investors with university-connected startups alongside the Carolina Growth Fund co-investment vehicle.

Gemelli BiotechMedicomPryon

Family office ("Second Foundation") founded by Bill Spruill after the roughly $300M sale of Global Data Consortium to the London Stock Exchange Group in 2022, run by a five-person full-time team from Raleigh. Its stated focus is founder wealth creation on two tracks: deep-tech and big-tech founders in the RTP region, and people-of-color technology founders nationwide, combining for-profit investing with philanthropic programs. Programs include founder education on equity preservation, investor matchmaking, and the Minority Achievers Initiative, a national cohort of big-tech and deep-tech founders run with American Underground (first cohorts October 2024 and January 2025). Spruill's angel record includes DocFox (sold to nCino), Union Metrics (sold to TrendKite/Cision), Magnus Health (private-equity acquisition), and Loqate (acquired by GB Group), with more than 80 companies mentored; he serves on the boards of CED and Triangle Family Services and as a Non-Executive Director of nCino.

iOrganBioPPersistence Therapeutics

Durham growth-equity fund for B2B software companies in underserved regions, founded by Joe Colopy and Kevin Mosley and part of Colopy Ventures alongside Primordial Ventures and GrepBeat. Fund I closed oversubscribed at $30M (January 2022 vintage). Writes $1.5M to $3M initial checks for large minority stakes in companies at $2M to $6M ARR, and publishes an annual B2B SaaS benchmarks report.

Cycle LabsCorevist

Strategy and Corporate Development Consultant | Board Member | Investor | Advisor. 25 years of experience, ~$7B in cumulative deal value. Triangle-based individual investor and board/advisor across multiple local software companies. Per-company roles: Scale Social AI — investor (Oct 2025) and advisor; Bull City Venture Partners — investor and advisory board member; Levitate — board member.

Scale Social AILevitate

Raleigh early-stage venture firm investing in physical and industrial technology across the Southeast, founded 2018. Typical checks run $500K to $1.5M from pre-seed through Series A. OPC Opportunity Fund I LP filed a Form D on 2025-01-15 recording $9,660,000 sold against a $20,000,000 offering, with Justin Wright-Eakes as a related person.

ExtellisNALA Membranes

Individual investor who has run a private family office in the Triangle since 2015 and, by his own account, backed one Morrisville drug-development team across three companies: seed positions in Neuronex (2011) and Aerial BioPharma (2011) and a Series A position with an advisory board seat at Arrivo BioVentures (2016). Investor and board member at Betr Health (Raleigh) since 2015. Also founder and CEO of Pinnacle Hospitality Partners, a Triangle hotel management and development company, and a limited partner in Frist Cressey Ventures (chair of the LP committee for Funds II and III) and HCG Digital Ventures. Positions are self-reported on his public LinkedIn profile as supplied by Adam on 2026-09-18; Arrivo's releases confirm private investors participated in both rounds without naming them.

Individual angel investor, distinct from his family office 2ndF, which has its own row. Founder of Global Data Consortium (sold to the London Stock Exchange Group in 2022 for roughly $300M). His personal angel record per GrepBeat (2025-04-15) includes DocFox (sold to nCino), Union Metrics (sold to TrendKite/Cision), Magnus Health (private-equity acquisition) and Loqate (acquired by GB Group), with more than 80 companies mentored. Named personally, alongside Tweener Fund and Scot Wingo, as an investor in Flytes (Cary) per the company's Wefunder page as recorded in its directory enrichment note. Serves on the boards of CED and Triangle Family Services and as a non-executive director of nCino.

Flytes

Cary early-stage investment group backing medical technology, industrial technology, clean or green technology, and B2B SaaS companies. Harbright Ventures led SonoVascular's $6M Series A first close in 2026.

SonoVascular

Early-stage VC focused on digital disruption. 62+ companies.

InsightFinder

Angel network in the Research Triangle Park region focused on seed and early-stage, technology-centric companies near revenue.

NALA Membranes

Individual angel investor, distinct from the NC Tweener Fund, where he has been a general partner since January 2022 and which has its own row. Four-exit Triangle founder: Stingray Software (acquired by Rogue Wave, 1999), ChannelAdvisor (founder and CEO from 2001 to 2015 through its 2013 IPO, board member to 2022), Spiffy (co-founder and CEO, 2017 to 2024), and now co-founder and CEO of ReFiBuy.ai (2025). Named personally, alongside Tweener Fund and Bill Spruill, as an investor in Flytes (Cary) on the company's Wefunder page, which lists the fund and the individual separately. NC State alumnus (Master of Computer Engineering).

Flytes

BDIP Fund II, L.P. filed a Form D on 2025-04-24 recording $159,476,621 sold from 4350 Lassiter at North Hills Avenue, Raleigh; related persons include Adam Daigle and Chris Burnham.

Founder-led pre-seed partnership in Downtown Durham. $5K angel checks plus deal-by-deal SPVs up to $100K. Post-product, often first check in.

Filed a Form D on 2025-06-02 recording $42,181,818 sold against a matching offering from 321 E Chapel Hill Street, Durham; related persons include Dhruv Patel and John Mansfield.

Sector-focused venture fund. Dental Innovation Alliance VC Fund I, LP filed a Form D on 2025-04-30 recording $26,225,000 sold from a Cary address; related persons include Thomas Sharpe and Mark Friedman.

Healthcare venture firm. Echo Innovation Alliance LLC filed a Form D on 2026-01-21 recording $207,361,038 sold from a Durham address.

102-company portfolio. 4 IPOs, 13 acquisitions.

Durham venture capital and commercial development firm focused on life-science, agriculture, and technology companies. The firm operates Pappas Ventures, Specialized Fund Management, and Translational Medicine; Pappas Ventures reports six funds raised, 40 IPO or M&A transactions across the portfolio, four companies sold for $1B or more, and 27 approved products developed by portfolio companies.

Person Street Partners GP Fund I, L.P. filed a Form D on 2025-09-11 recording $9,800,000 sold against a $20,000,000 offering from 4000 Centregreen Way, Cary; related persons include Jacob Jatis and Poojan Mehta.

Lower-middle-market investment firm. Plexus Fund VII-A, L.P. filed a Form D on 2025-05-14 recording $102,000,000 sold from 4242 Six Forks Road, Raleigh.

Small-business acquisition investment firm. Prudent Growth Fund III, LLC filed a Form D on 2026-03-24 recording $23,825,000 sold against an $80,000,000 offering from 141 Providence Road, Chapel Hill.

Healthcare and life-sciences investment firm. Filed Form Ds for QHP Private Equity Fund III-A ($262,231,000) and III-B ($172,850,000) on 2025-12-18 from a Raleigh address; related persons include Vern Davenport, Ashton Poole, and Ryan Applegate.