Durham · North Carolina

126 Durham startups

126 startups headquartered in Durham are tracked in the Triangle Startups directory, with the largest clusters in SaaS, Biotech, and Healthtech. Durham is home to Duke University and the American Underground startup hub. Every company here is sourced by hand from primary records, then linked to its full profile.

SaaS34Biotech23Healthtech18MedTech14

Directory snapshot

What the Durham startup directory shows

SaaS is the largest recorded cluster, with 34 startups. Of 92 startups with a recorded funding stage, 53 are at grant, pre-seed, or seed. Reviewed jobs records currently show 69 open roles across 23 companies.

tracked startups: 126
in SaaS: 34
grant through seed: 53

By stageGrant23Growth19Seed16Pre Seed14Series A11

Hiring in Durham

69 reviewed open roles

See the jobs board

CareYaya9 rolesHealthtechConnecting pre-health students with families for affordable elder care

Higharc9 rolesSaaS · Series CHomebuilding AI platform for design, estimating, sales, and construction workflows.

Pairwise6 rolesAgTech · GrowthDurham agricultural biotechnology company using its Fulcrum CRISPR platform to develop and license gene-edited crop traits for more resilient, nutritious, and sustainable food and agriculture.

Vulcan Elements5 rolesDeepTech · GrowthRare-earth magnet manufacturer building a domestic supply chain for defense and commercial applications.

Headwater Science4 rolesHealthtechDurham healthcare data company developing statistical methods and software for real-world evidence research. Formerly NoviSci; acquired by Target RWE in 2021 and renamed Headwater Science in 2026.

Pluto Health4 rolesHealthtech · Series AAI clinical intelligence connecting fragmented health data

Local startup infrastructure

Where Durham startups build

Accelerators, venture studios, and other local programs that work directly with founders in Durham.

Grants & FoundationNC IDEAIndependent private foundation supporting North Carolina entrepreneurs through non-dilutive grants and programming. Three active grant tiers form a ladder by check size and program intensity: MICRO for early validation, SEED for growth-stage scaling, Bold Path for under-resourced founders pursuing entrepreneurship full-time. SOAR serves additional founder cohorts.Talent ProgramThe Seed ListDurham nonprofit matching current students into meaningful technical work at Research Triangle startups. The summer program pairs student teams with startup projects, mentorship from The Seed List team, and workspace access through American Underground.Talent ProgramCode the DreamDurham nonprofit offering free software-development classes and paid apprenticeships for people from backgrounds underrepresented in tech. CTD Labs builds client software with senior developers mentoring apprentices. Employer partnerships connect companies with trained developers; joining is free, while the Tandem managed apprenticeship is separately priced and scoped.AcceleratorKnox Street StudiosDurham community-builder at 1307 W Knox St, operated by AB Community (501(c)(3)). Programs span three pillars: entrepreneurship (Startup Weekend Durham, Launch Lab early-stage accelerator, and Launch Proof, a twelve-session accelerator for Durham business owners run with the City of Durham), STEM education, and community events. Strong support for diverse and underrepresented founders. Backed by Google, the City and County of Durham, NC IDEA, and others.CoworkingAmerican UndergroundDowntown Durham coworking and startup community at 324 Blackwell St (the ATC building). Long-running Triangle startup hub; hosts member companies, partner events, and community gatherings, including Startup Weekend Durham VII (May 2026).CoworkingReCity NetworkShared workspace at 112 Broadway Street in downtown Durham for nonprofits, social enterprises, founders and remote workers. Offers coworking memberships, private offices, conference rooms and event space, with community programs including Coffee Conversations and Free Coworking Day.Business SupportCEDThe Council for Entrepreneurial Development, a nonprofit running since 1984 that puts founders, investors and community partners in one network. Programs run in three communities: Forge for founders (membership, the GRO incubator), Connect for partners (Strength in Numbers, students), and Accelerate for investors (Dealroom). Its public events calendar is the densest single source of founder programming in the Triangle, and much of it is open to non-members. Annual Venture Connect conference at DPAC in Durham.Business SupportDurham Tech Small Business CenterDurham Technical Community College's small-business center, with offices in downtown Durham at 701 W. Main St. and in Chapel Hill at 136 E. Rosemary St. New and existing business owners can book free, one-on-one counseling, take free seminars and webinars on business skills, and use its library of business books and local resources.

Startups headquartered in Durham

410 Medical

Healthtech · Growth

5Metis

AgTech · Grant

Adwerx

SaaS · Series A

AKALAKA

Healthtech · Grant

Altis Biosystems

Biotech · Seed

Arbiom

Biotech · Growth

Argoneta

DeepTech · Grant

Arpio

SaaS · Series A

Artificially Digital

SaaS · Pre Seed

ARtx

DeepTech · Pre Seed

Atsena Therapeutics

Biotech · Series C

Avalo

AgTech · Series A

baebies

MedTech · Growth

BioAesthetics

MedTech

BotBuilt

Climate

Bristles

Consumer · Seed

CareYaya

Healthtech

Cell Microsystems

Biotech · Grant

Centervention

EdTech

Coco Fro

Consumer · Grant

Counterforce Health

Healthtech · Grant

Courtroom5

SaaS · Grant

CytexOrtho

MedTech

DayOf

SaaS

DNAli Data Technologies

DeepTech · Seed

eBoxchain

Healthtech

Ecree

EdTech · Grant

Elo Life Systems

AgTech · Growth

Elroi Enterprise

SaaS · Pre Seed

Entegrion

MedTech

Extellis

DeepTech · Seed

EydisBio Inc.

Biotech · Grant

FlexGen Power Systems

Climate · Growth

Focus Cubes

Healthtech · Grant

ForagR Medicines

Biotech

Founder Readiness Institute

SaaS

Gateway Bio

Biotech

GeneCentric

Biotech · Series C

Ghee Guy

Consumer

Gradient Health

Healthtech

Grid Intelligence

Climate · Pre Seed

Grid Therapeutics

Biotech

GTM Buddy

SaaS · Series A

Harmony

Healthtech · Seed

Hayti

Consumer · Grant

HeirShares

SaaS · Grant

Helian

Healthtech · Pre Seed

Higharc

SaaS · Series C

HomeCloud

SaaS

IMMvention Therapeutix

Biotech

Innatrix

AgTech · Grant

InsightFinder

SaaS · Series B

inSoma Bio

MedTech · Seed

IOTA Software

SaaS · Growth

Jeani

Healthtech · Pre Seed

Kahmino

SaaS · Seed

Keebler Health

SaaS · Series A

Kevel

SaaS · Series C

Kriya Therapeutics

Biotech · Growth

Levee Medical

MedTech · Series B

Levita Health

MedTech

LoanWell

Fintech · Grant

Looks AI

Consumer · Pre Seed

LOOM3D

Climate

Looma

SaaS · Series B

Lumedica

MedTech

Lumius

MedTech · Pre Seed

MAA Laboratories

Biotech

MaiaZura

EdTech · Seed

Majentics

SaaS · Grant

Metabolon

Biotech · Growth

mindr

Healthtech · Grant

Moments

Healthtech

momnt.

Consumer · Pre Seed

Opine

SaaS · Seed

OraLiva

MedTech

Pairwise

AgTech · Growth

Pelthos Therapeutics

Biotech · Growth

PeopleLogic

SaaS

Phononic

Climate

Pluto Health

Healthtech · Series A

Precision BioSciences

Biotech · Growth

PROTECT3D

Healthtech · Seed

Ramona Optics

Biotech · Series A

Reselute

MedTech · Seed

restor3d

MedTech · Growth

RevBoss

SaaS · Grant

Ribometrix

Biotech · Series A

Roke Biotechnologies

Biotech

RoundUp

Fintech

Rozie Synopsis

SaaS · Seed

Sennos

Biotech · Growth

Serv Technologies

SaaS · Pre Seed

ServiceTrade

SaaS · Growth

Sift Media

SaaS · Seed

SiNON Nano Sciences

Biotech · Grant

SnapPicFix

SaaS · Grant

Spiffy

SaaS

Spreedly

Fintech

Stashpad

SaaS

Strata Solar

Climate · Growth

Students Who Sit

Consumer · Grant

Sustaera

Climate · Series A

Syllaby

SaaS

Synapse Semiconductor

DeepTech

Teamworks

SaaS · Growth

Tellus Therapeutics

Biotech · Series A

Ten63 Therapeutics

Biotech · Series B

The Alchemy Lab

SaaS

The Social Institute

EdTech

Theia Imaging

MedTech

Toilemetry

Healthtech · Pre Seed

Tromml

SaaS · Grant

Tune Therapeutics

Biotech · Series B

Upstream Biotechnology

AgTech · Seed

Upswing

EdTech · Series A

Vega Health

Healthtech · Seed

Ver Coaching

Healthtech · Pre Seed

Verinetics

MedTech · Grant

Vestaron

AgTech · Growth

Voice Back

Healthtech · Pre Seed

VoxIntel AI

SaaS · Pre Seed

Vulcan Elements

DeepTech · Growth

Warrant

SaaS · Seed

Windlift

DeepTech · Grant

Written Word Media

Consumer · Growth

Exited companies headquartered in Durham

These companies have been acquired, taken private, or taken public, so each is listed with its exit and left out of the startup count above.

Cereius

Biotech

Acquired by Solve Therapeutics, 2023, terms not disclosed

GrassRoots Biotechnology

AgTech

Acquired by Monsanto, 2013, terms not disclosed

Headwater Science

Healthtech

Acquired by Target RWE, 2021

Higgs Boson Health

Healthtech

Acquired by Globus Medical, 2026, terms not disclosed

InnAVasc Medical

MedTech

Acquired by W. L. Gore & Associates, 2022, terms not disclosed

Opus Genetics

Biotech

Acquired by Ocuphire Pharma, 2024, terms not disclosed

SonoVol

MedTech

Acquired by PerkinElmer, 2022, terms not disclosed

Wolfspeed

DeepTech

Public since 1993

Browsing is free. Opening a company shows the basics; founders, funding, and signals are in the full profile behind a free account. Open roles across Triangle companies are tracked on the jobs page. Numbers refresh from the database.